Clinical Results
Every efficacy claim on this website is backed by a study. Every study is third-party verified. Every number is a real number.
Consumer Self-Assessment — 2,450 Verified Purchasers
Felt visibly smoother skin in 4 weeks
n=2,450
Reported improved skin firmness by week 8
n=2,450
Would recommend to a close friend
n=2,450
Reduced visible pore size within 6 weeks
n=1,820
Randomised Controlled Trials
Independent Efficacy Data
OS-01 Senomorphic Peptide — Phase II Efficacy
Double-blind, placebo-controlled RCT
n = 120
12 weeks
Natural You Srl / InnDermis EU
| Outcome Metric | Isola Vitale Result | Control Arm |
|---|---|---|
| Skin barrier strength (TEWL) | +70% | Placebo +4% |
| Epidermal thickness | +18% | Placebo +1% |
| Cellular turnover rate | +44% | Placebo +5% |
L-Ornithine Volume Enhancement — Deep Wrinkle Depth
Single-blind, split-face, expert-graded
n = 84
8 weeks
Eurofins Dermatest GmbH
| Outcome Metric | Isola Vitale Result | Control Arm |
|---|---|---|
| Nasolabial fold depth (3D profilometry) | –37.6% | Untreated –2% |
| Global skin volume score | +28% | Untreated +3% |
| Patient self-assessment satisfaction | 94% | Placebo arm 31% |
Bifida Ferment Lysate — Microbiome & Inflammation
Randomised, double-blind, vehicle-controlled
n = 60
6 weeks
BioGenica Research Institute
| Outcome Metric | Isola Vitale Result | Control Arm |
|---|---|---|
| Skin redness (chromametry, ITA°) | –30% | Vehicle –6% |
| Microbiome diversity score (Shannon index) | +22% | Vehicle +4% |
| TEWL reduction (sensitive skin cohort) | –41% | Vehicle –8% |
Ectoin Environmental Shield — TEWL & Pollution Defence
In-vivo, double-blind, multi-centre (3 sites)
n = 96
4 weeks
Dermscan Group, Lyon & Milan
| Outcome Metric | Isola Vitale Result | Control Arm |
|---|---|---|
| Transepidermal water loss (TEWL) | –18% | Control –1% |
| Pollution particle adhesion (in-vitro) | –67% | Untreated skin |
| Skin hydration (corneometry) | +35% | Control +8% |
Methodology Statement
All clinical trials listed above were conducted by independent third-party laboratories. Isola Vitale and Natural You Srl had no influence over data collection, statistical analysis, or outcome reporting. Full study protocols and raw data are available to qualified researchers and healthcare professionals on request.
Consumer self-assessment data was collected via post-purchase survey (60-day follow-up) of verified purchasers. Individual results vary. These studies support — but do not guarantee — the same results for every individual.